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Cancer chemotherapy is the use of drugs to kill cancer cells. Unlike radiation and surgery, which are localized treatments, chemotherapy is a systemic treatment, meaning the drugs travel throughout the whole body. This means chemotherapy can reach cancer cells that may have spread, or metastasized, to other areas.
Chemotherapy is usually combined with other types of treatment (surgery, radiation therapy) in an attempt to do the following:
Gemcitabine, used alone or in combination with other chemotherapy agents, seems to improve the quality of life for patients with pancreatic cancer. Chemotherapy with gemcitabine improves symptoms, including pain, nausea, and vomiting in about 25% of patients. It also provides a modest increase in survival (usually only a few months).
Fluorouracil is not associated with a survival benefit. Cisplatin and some other drugs have been used in combination with gemcitabine, but are associated with more side effects.
These drugs should be used with caution in the elderly and those with liver or kidney disease . Elderly patients are at an increased risk of side effects.
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Lohr JM. Medical treatment of pancreatic cancer. Expert Rev Anticancer Ther. 2007;7:533-544.
What you need to know about cancer of the pancreas. National Cancer Institute website. Available at: http://www.cancer.gov/cancerinfo/wyntk/pancreas#2 . Accessed April 8, 2009.
Yip D, Karapetis C, Strickland A, et al. Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer. Cochrane Database Syst Rev. 2006;3:CD002093.
Last reviewed September 2014 by Mohei Abouzied, MD, FACP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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