Widely used in Chinese herbal medicine, the herb corydalis is said to alleviate pain by “moving qi” and “stimulating the blood.” These expressions refer to traditional concepts included within the complex theories of traditional Chinese herbal medicine . In terms of Western diagnostic categories, corydalis may be recommended for soft tissue injuries , menstrual discomfort , and abdominal pain.
The part of the plant used medicinally is the rhizome (underground stalk).
There is no reliable evidence that corydalis or its constituents offer any medicinal benefits. Corydalis contains a number of active and potentially dangerous chemicals in the alkaloid family, including tetrahydropalmatine (THP), corydaline, protopine, tetrahydrocoptisine, tetrahydrocolumbamine, and corybulbine. Of these, THP may be the most active, as well as the most toxic (see Safety Issues ).
Only double-blind , placebo-controlled studies can actually show that a treatment works, and there is only one such study that is relevant to corydalis. This trial tested THP as a treatment for a type of heart rhythm abnormality called supraventricular arrhythmia. 1 Reportedly, use of THP produced significant benefits as compared to placebo. However, this study was conducted in China, and there is considerable skepticism about the validity of Chinese medical trials. 2 (For information on why double-blind studies are essential, see Why Does This Database Rely on Double-blind Trials? )
Much weaker evidence from animal and test-tube studies hint that TNP or corydalis extracts might have pain-relieving, sedative, and anti-inflammatory effects. 3-5 Corydalis constituents may also affect neurotransmitters in the brain, including dopamine and GABA. 6-7 Equally weak evidence hints at benefits for preventing or treating cataracts , 8 reducing blood coagulation, 9 and lowering blood pressure . 10 However, none of this research remotely approaches the level of evidence that can prove a treatment effective.
Corydalis is usually taken at a dose of 5–10 grams daily, or equivalent quantities of an extract.
Corydalis has not undergone any meaningful safety testing. The herb is known to produce immediate side effects, including nausea and fatigue, in some people. In addition, there are serious safety concerns related to its alkaloid constituent THP. Use of products containing THP has repeatedly been associated with severe and potentially fatal liver injury. 11-16
In addition, there are three reports that use of THP by young children has led to life-threatening suppression of the central nervous system. 17
For these reasons, we strongly recommend against the use of corydalis, especially by young children, pregnant or nursing women, or people with liver disease.
3. Reimeier C, Schneider I, Schneider W, et al. Effects of ethanolic extracts from Eschscholtzia californica and Corydalis cava on dimerization and oxidation of enkephalins. Arzneimittelforschung . 1995;45:132–6.
6. Kleber E, Schneider W, Schafer HL, et al.. Modulation of key reactions of the catecholamine metabolism by extracts from Eschscholtzia californica and Corydalis cava . Arzneimittelforschung . 1995;45:127–31.
8. Kubo M, Matsuda H, Tokuoka K, et al. Studies of anti-cataract drugs from natural sources. I. Effects of a methanolic extract and the alkaloidal components from Corydalis tuber on in vitro aldose reductase activity. Biol Pharm Bull . 1994;17:458–9.
Last reviewed September 2014 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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