Asthma is a chronic lung disease. When asthma strikes, airways in the lungs become swollen and constricted, causing coughing, wheezing, and difficulty breathing.
Allergic rhinitis, also called hay fever, is an allergic response by your immune system to pollens, mold, and dust. Symptoms include stuffy, runny, or itchy nose, and sneezing.
Asthma and allergic rhinitis can be triggered by many of the same allergens. And, in both conditions, leukotrienes add to the development of symptoms. Leukotrienes are chemicals that cause inflammation, mucous secretion, and constriction in your lungs.
Leukotriene inhibitors are medicines that decrease inflammation by preventing the action of leukotrienes. These types of medicines are not used to relieve acute symptoms, but can be used to prevent your symptoms from occurring.
Examples of leukotriene inhibitors that are available include:
Some of the most common side effects with these drugs are:
While rare, liver problems can occur while taking leukotriene inhibitors. These drugs can also cause mental health problems, like mood or behavior changes. If you are prescribed a leukotriene inhibitor, be sure that you report any side effects to your doctor.
You may not be able to take a leukotriene inhibitor if you:
If you have asthma or allergic rhinitis and want relief from your symptoms, talk to your doctor or get a referral to an allergy specialist. Depending on your condition and overall health, leukotriene inhibitors may be a good choice for you.
Food and Drug Administration
National Institute of Allergy and Infectious Diseases
Allergy Asthma Information Association
Asthma. American Academy of Allergy Asthma & Immunology website. Available at: http://www.aaaai.org/conditions-and-treatments/asthma.aspx. Accessed February 2, 2017.
Leukotriene blocking drugs one year later. Partners Healthcare website. Available at: http://www.asthma.partners.org/NewFiles/BoFAChapter16.html. Accessed February 2, 2017.
Leukotriene modifiers. Palo Alto Medical Foundation Sutter Health website. Available at: http://www.pamf.org/asthma/medications/oral/leukotrines.html. Accessed February 2, 2017.
Montelukast. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T232771/Montelukast. Updated December 7, 2016. Accessed February 2, 2017.
Rhinitis (hay fever). American Academy of Allergy Asthma & Immunology website. Available at: http://www.aaaai.org/conditions-and-treatments/allergies/rhinitis.aspx. Accessed February 2, 2017.
Scow DT, Luttermose GK, Dickerson KS. Leukotriene inhibitors in the treatment of allergy and asthma. American Family Physician. 2007;75:65-70.
Singulair. DailyMed website. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8c166755-7711-4df9-d689-8836a1a70885. Updated June 30, 2016. Accessed February 2, 2017.
Updated information on leukotriene inhibitors: montelukast (marketed as Singulair), zafirlukast (marketed as Accolate), and zileuton (marketed as Zyflo and Zyflo CR). US Food and Drug Administration website. Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm165489.htm. Published August 28, 2009. Accessed February 2, 2017.
Zafirlukast. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T238045/Zafirlukast. Updated December 7, 2016. Accessed February 2, 2017.
Zileuton. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T233520/Zileuton. Updated January 18, 2013. Accessed February 23, 2015.
Last reviewed February 2017 by Michael Woods, MD, FAAP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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