Since there are only a few medications available to slow the progress of Alzheimer disease, many companies are promoting the use of certain supplements to prevent and treat memory problems. Scientists are investigating the effects of these supplements, but for the most part, there is little to no evidence to support their claims. There is no supplement that has survived rigorous scientific evaluation to prove that it is consistently helpful in fighting Alzheimer’s disease.
There are several different types of supplements that have been studied to see if they improve function in adults with Alzheimer disease or prevent the risk of Alzheimer disease in adults who do not yet have impaired function.
An excess of free radicals (also known as oxidants) may contribute to the development of Alzheimer disease. Antioxidants theoretically may protect against Alzheimer’s disease by limiting the buildup of toxic amyloid protein. Diets rich in foods containing antioxidant vitamins, such as E and C, have been associated with a reduced risk of Alzheimer disease. However, the supplement forms of these vitamins have not shown the same association. Also one randomized trial failed to show that vitamin E supplementation prevented Alzeimer's disease. A meta-analysis noted an increase risk of death (due to all causes) in patients taking high doses of vitamin E. But, based on the evidence so far, it does not appear that supplements are useful for the prevention of Alzeimer disease.
Gingko biloba, thought to help deliver oxygen to the brain by improving blood flow to capillaries, is the most widely used herb to improve cognitive function. However, the overall data thus far is inconclusive. Some studies have found some benefit as a treatment in improving cognitive function in patients with dementia while others have not.
Huperzine A, an extract from a club moss, may hold promise for people with Alzheimer’s disease by inhibiting the enzyme that breaks down the neurotransmitter acetylcholine (which carries information in the brain). There is some evidence in animal studies that it may have benefit. It also may have some benefit as a treatment for patients who already have Alzeimer's disease. However, there is no indication that it can stave off memory loss in healthy people.
Evidence is also mixed for vinpocetine, a chemical derived from vincamine (found in the leaves of the periwinkle plant). Vinpocetine is thought to enhance memory and mental function by improving circulation in the brain and helping the brain to use oxygen more efficiently. More research is needed in this area.
There are a number of other essential nutrients that are also purported to improve cognitive function. These include:
Carnitine, a derivative of the amino acid lysine, plays an important role in energy production. Several small trials have suggested that it can modestly slow cognitive decline in patients with AD. Overall, literature reviews suggested that it may only be mildly helpful at best for Alzheimer disease.
Phosphatidyl serine and choline are both involved in the structure and maintenance of cell membranes. Phosphatidyl serine has been shown to be mildly effective in the early stages of Alzheimer’s disease. Clinical trials of choline alfoscerate have also shown some promise.
It has been suggested that a dietary deficiency of omega-3 and omega-6 (essential) fatty acids could be a risk factor for Alzheimer disease. Evidence appears to be mixed. One review of 3 studies found that omega-3 fish oil supplements did not improve cognitive function in healthy adults over 60 years old. In contrast, 3 observational studies found that eating fish 2 or more times a week reduced risk of dementia and Alzheimer disease compared to those who did not eat fish. From these studies, it appears that evidence supports eating fish, but not taking pills with these fatty acids in them.
Buyers should beware that products that are natural are not necessarily safe or good for you. Remember that a healthy diet will likely provide you with adequate vitamins and minerals. Talk to your doctor before taking vitamins and supplements. The more medications you take, the greater the risk of an adverse reaction from a drug interaction.
Clearly, the market for memory enhancers is huge. As the population ages, interest in ways to slow or stop the progression of Alzheimer’s disease will only continue to grow. Unfortunately, since further research is needed, it may be years before the benefits and risks of supplements are fully established. Moreover, supplements are expensive.
In the meantime, consider that by exercising, eating right, and using your mind—reading books, playing games, learning a new language—you will improve your chances of preserving mental acuity. It may not be as simple as popping a pill, but the gains are worth it.
National Institute on Aging
Alzheimer Society of Canada
Alternative treatments Alzheimer's Association website. Available at: http://www.alz.org/alzheimers_disease_alternative_treatments.asp. Accessed December 13, 2016.
Alzheimer dementia. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114193/Alzheimer-dementia. Updated November 19, 2014. Accessed December 13, 2016.
Alzheimer's disease and non-Alzheimer's dementia. EBSCO Natural and Alternative Treatments website. Available at: http://www.ebscohost.com/biomedical-libraries/natural-alternative-treatments. Updated December 15, 2015. Accessed December 13, 2016.
Antioxidants: In depth. National Center for Complementary and Integrative Health website. Available at: https://nccih.nih.gov/health/antioxidants/introduction.htm. Updated May 4, 2016. Accessed December 13, 2016.
Dietary supplements and cognitive function, dementia, and Alzheimer's disease: What the science says. National Center for Complementary and Integrative Health website. Available at: https://nccih.nih.gov/health/providers/digest/alzheimers-science. Updated November 19, 2015. Accessed December 13, 2016.
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Mancuso C, Bates TE, Butterfield DA, et al. Natural antioxidants in Alzheimer's disease. Expert Opin Investig Drugs. 2007;16(12):1921-1931.
Last reviewed December 2016 by Michael Woods, MD, FAAP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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