Pronounced: hye-POK-sik is-KEM-ik en-sef-a-lo-path-ee
Hypoxic ischemic encephalopathy (HIE) is a condition in which the brain does not receive enough oxygen.
HIE can be fatal. Brain cells can begin dying within as little as five minutes without oxygen. The disease can also cause long-term damage, including intellectual disability, seizures , and cerebral palsy .
Blood Supply to the Brain
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There are a variety of causes of HIE. Any injury and many health conditions can cause a lack of oxygen to the brain. Some common causes are:
Any injury, complication, or condition that causes the brain to have a reduction in blood flow and oxygen is a risk factor for HIE.
A physical exam will be done. Typically, the history is the most important factor in making the diagnosis.
Tests may include the following:
Treatment depends on the underlying cause of the condition, as well as the severity of the damage to the brain. Treatment options include:
In most cases, HIE is sudden and cannot be prevented. CPR may be given to prevent significant or long-term brain damage after the oxygen supply has been reduced.
Brain Injury Association of America
National Institute of Neurological Disorders and Stroke
Ontario Brain Injury Association
Brain injury secondary to carotid intervention [review]. J Endovasc Ther . 2007;14:219-231.
Hemphill J, Smith W. Neurologic critical care, including hypoxic-ischemic encephalopathy and subarachnoid hemorrhage. In: Fauci AS, Braunwald E, Kasper DL, et al. Harrison's Principles of Internal Medicine . 17th ed. New York, NY: McGraw-Hill; 2005: chap 269.
Hypoxic ischemic encephalopathy (HIE). Neurographics website. Available at: http://www.neurographics.org/2/1/1/4.shtml . Accessed February 19, 2013.
Itoo BA, Al-Hawsawi ZM, Khan AH. Hypoxic ischemic encephalopathy. Incidence and risk factors in North Western Saudi Arabia. Saudi Medical Journal . 2003;24:147-153.
Last reviewed February 2013 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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