Anakinra (Kineret) is FDA-approved to treat adults with pain and swelling caused by moderate to severe active rheumatoid arthritis (RA) who have not found relief from other treatments.
Anakinra blocks the action of the protein interleukin-1 (IL-1). IL-1 is produced in excessive amounts in people with RA. High levels of IL-1 contribute to the joint pain, swelling, and stiffness of RA. By blocking IL-1, anakinra can help reduce these symptoms.
You may need to take anakinra for several weeks before your RA symptoms begin to improve.
Anakinra is given once a day as an injection. If you are prescribed anakinra, the doctor or nurse will teach you how to give yourself the injection so that you can do it at home.
The main side effect of this drug is mild redness, swelling, and pain at the injection site. Other side effects include:
Anakinra is not for everyone with RA. Talk to your doctor before taking anakinra if you:
If you are prescribed anakinra, there are other precautions that you should take, such as:
If you have tried other RA medicines and have not had any relief from your symptoms, talk to your doctor to find out if anakinra is a good option for you.
US Food and Drug Administration
The Arthritis Society
Canadian Pharmacists Association
American Society of Health-System Pharmacists. Anakinra. PubMed Health website. Available at: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000183. Updated February 1, 2009. Accessed September 12, 2012.
Anakinra (Kineret) FDA approved for use in rheumatoloid arthritis. American College of Rheumatology website. Available at: http://www.rheumatology.org/publications/hotline/1101anakinra.asp. Updated November 2001. Accessed September 12, 2012.
Bresnihan, B, Alvara-Gracia, JM, Cobby, M, et al. Treatment of rheumatoid arthritis with recombinant human IL-1 receptor antagonist. Arthritis Rheum 1998; 41:2196.
Anakinra. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated December 14, 2011. Accessed September 12, 2012.
Fleischmann, RM, Schechtman, J, Bennett, R, et al. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial. Arthritis Rheum 2003; 48:927.
Patient information on anakinra. Austrailian Rheumatology Association website. Available at: http://www.rheumatology.org.au/downloads/anakinraCo-Badged15.09.pdf. Updated September 2011. Accessed September 12, 2012.
Last reviewed September 2012 by Brian Randall, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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