Charcot-Marie-Tooth (CMT) disease is a group of genetic disorders that affects movement and feeling in the limbs. The disease progresses slowly and causes damage to the peripheral nerves. These nerves control muscles and transmit sensation.
CMT is caused by defects in specific genes, called a genetic mutation.
CMT can be classified in a number of ways:
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Usually, symptoms first appear in children and young adults. The first sign of CMT is often a high arched foot or difficulty walking. Other symptoms may include:
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Although there is no cure for CMT, treatment may help to improve function, coordination, and mobility. Treatment is also vital to protect against injury due to muscle weakness and reduced sensation. Treatment may include:
National Institute of Neurological Disorders and Stroke
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Peroneal muscular atrophy. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated Updated November 7, 2012. Accessed January 31, 2013.
Reilly MM, Murphy SM, Laura M. Charcot-Marie-Tooth disease. J Periph Nerv Syst . 2011;16(1):1-14.
Last reviewed September 2012 by Kari Kassir, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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