Pancreatic cancer is the growth of cancer cells in the pancreas. The pancreas is a long, flattened pear-shaped organ in the abdomen. It makes digestive enzymes and hormones, including insulin.
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Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.
It is not clear exactly what causes these problems in the cells, but it is probably a combination of genetics and environment.
Pancreatic cancer is more common in men, and in people aged 40 years and older. Other factors that may increase your chance of pancreatic cancer include:
Pancreatic cancer does not cause symptoms in its early stages. The cancer may grow for some time before it causes symptoms. When symptoms do appear, they may be very vague. In many cases, the cancer has spread outside the pancreas by the time it is discovered.
Symptoms will vary depending on the location and size of the tumor. Pancreatic cancer may cause:
The doctor will ask about your symptoms and medical history. A physical exam will be done. The doctor may order blood and urine tests, as well as check for hidden blood in your stool.
Imaging tests evaluate the pancreas and surrounding structures:
Your doctor may also want to take a biopsy—removal of a sample of pancreatic tissue for examination under a microscope
The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used to guide your treatment plan. Like other cancers, pancreatic cancer is staged from I-IV. Stage I is a very localized cancer, while stage IV indicates a spread to other parts of the body.
Treatments for pancreatic cancer depends on the stage of the cancer. Treatments include:
Removal of the cancerous tumor and nearby tissue may be done. Nearby lymph nodes may also need to be removed. In pancreatic cancer, surgery may also be performed to relieve symptoms. Surgeries include:
This is the use of radiation to kill cancer cells and shrink tumors. Radiation therapy may be:
Chemotherapy is the use of drugs to kill cancer cells. It may be given in many forms including pill, injection, and via a catheter. The drugs enter the bloodstream. Chemotherapy also affects healthy cells.
The use of medications or substances made by the body. They can increase or restore the body's natural defenses against cancer. It is also called biologic response modifier (BRM) therapy.
Most times, pancreatic cancer is discovered at an advanced stage. Surgery may not be appropriate in this case. If surgery cannot be done, then chemotherapy and radiation are offered together to prolong survival.
Surgery would be appropriate in about a quarter of people with this disease in the early stage. In these cases, the person would benefit from surgery. After surgery, follow-up chemotherapy and radiation therapy have been found to prolong survival in some cases.
To help reduce your chance of pancreatic cancer:
American Cancer Society
Pancreatic Cancer Action Network
Canadian Cancer Society
Pancreatic Cancer Canada
Pancreatic cancer. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003131-pdf.pdf. Accessed August 25, 2014.
Pancreatic cancer. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated August 12, 2014. Accessed August 25, 2014.
Pancreatic cancer—for patients. National Cancer Institute website. Available at: http://www.cancer.gov/types/pancreatic. Accessed August 25, 2014.
9/23/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Boffetta P, Hecht S, Gray N, Gupta P, Straif K. Smokeless tobacco and cancer. Lancet Oncol. 2008;9(7):667-675.
7/21/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Li D, Morris JS, Liu J, et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA. 2009;301(24):2553-2562.
3/5/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Tramacere I, Scotti L, Jenab M, et al. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer. 2010;126(6):1474-1486.
Last reviewed September 2015 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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