Glioblastoma multiforme (GBM) is the most common glioma—a type of brain cancer. This cancer starts in the glial cells, which are cells that help nerve cells work.
This condition can develop suddenly. It can also develop from a lower grade, less cancerous brain tumor. Most cases are located in the cerebral hemisphere of the brain. The cancer can also begin in the spinal cord or brain stem.
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GBM originates from astrocytes, which are a type of glial cell. The factors that cause normal-functioning astrocytes to become cancerous is not well understood.
GBM is more common in people over 50 years old, especially those who are Caucasian, Hispanic, and Asian. Factors that increase your chances of developing GBM include:
You will be asked about your symptoms and medical history. A physical exam will be done.
Images and scans may be taken of your brain. This can be done with:
Your brain activity may be measured. This can be done with:
Your bodily fluids and tissues may be tested. This can be done with:
Surgery is often done to confirm diagnosis and relieve headache, but doctors cannot completely remove the cancer. Other types of treatment may include:
Even with aggressive treatment, few patients survive more than 5 years after diagnosis. However, there is evidence that medical and surgical intervention can increase life expectancy and improve quality of life.
A multi-disciplinary approach is important for you and your family. This approach may involve:
American Brain Tumor Association
National Brain Tumor Society
Brain Tumor Foundation of Canada
Canadian Cancer Society
Adult brain tumors treatment (PDQ). National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/adultbrain/healthprofessional. Updated June 5, 2015. Accessed June 11, 2015.
Glioblastoma. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated March 30, 2015. Accessed June 11, 2015.
Last reviewed June 2015 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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